374例金黄色葡萄球菌烫伤样皮肤综合征患儿病原菌及其药敏试验结果

Pathogenic Bacteria and Drug Sensitivity of 374 Cases of Children with Staphylococcal Scalded Skin Syndrome

目的：了解金黄色葡萄球菌烫伤样皮肤综合征患儿的病原菌检出情况及其药敏试验结果，为该疾病的临床治疗提供分析数据。方法：2010年1月～2015年6月我院收治的金黄色葡萄球菌烫伤样皮肤综合征患儿374例作为研究对象。采集患儿的创面分泌物和血液标本进行细菌培养和药敏试验。结果：创面分泌物标本中检出223株病原菌；血培养阳性17例。阳性．率4．55％。共检出金黄色葡萄球菌187株，其中耐甲氧西林金黄色葡萄球菌（MRSA）64株，检出率34．22％。甲氧西林敏感金黄色葡萄球菌（NSSA）和MRSA对万古霉素、替加环素、替考拉宁、利奈唑胺的敏感率均为100．00％；MRSA对青霉素、苯唑西林、哌拉西林、头孢哌酮、头孢唑林、头孢呋辛、头孢西丁、阿奇霉素、克林霉素的敏感率均为0。结论：金黄色葡萄球菌烫伤样皮肤综合征的病原学检查尤为重要，应根据药敏试验结果合理使用抗菌药物。

Objective： To understand the pathogen bacteria detection and drug sensitivity results in the children with staphylococ- cal scalded skin syndrome to provide data for the clinical treatment. Methods： Totally 374 children with staphylococcal scalded skin syndrome treated from January 2010 to June 2015 were selected. The childreng wound secretion and blood samples were collected, and bacterial culture and drug sensitivity test were carried out. Results： Totally 223 pathogenic bacteria were detected out in the wound se- cretion samples; 17 cases of blood culture were positive with the positive rate of 4.55% ; 187 strains of staphylococcus aureus were de- tected out; 64 strains of MRSA were found out with the MRSA detection rate of 34.22% （64/187）. The sensitivities of MSSA and MRSA to common antibacterial drugs were different. The susceptibility rates of MSSA and MRSA to vancomycin, teicoplanin, teicopla- nin and linezolid were all 100.00%. The sensitivity rates of MRSA to penicillin, oxacillin, piperacillin, piperacillin, cefoperazone so- dium, cefazolin, cefuroxime, cefoxitin, azithromycin and clindamycin were all zero. Conclusion： The pathogenic examination of staphylococcal scalded skin syndrome is very important, and antibiotics should be used reasonably＇according to the results of drug sensi- tivity.