1例头孢吡肟引起神经系统损害的病例分析

Analysis of One Case of Nervous System Damage Caused by Cefepime

目的:通过1例病例分析,总结头孢吡肟引起神经系统损害的一般规律,并根据临床特点给予合理化建议。方法:临床药师根据患者的病情变化,查阅文献,从患者的临床表现到所用药物排除其他原因,从给药时间、给药剂量、药物相互作用、停药后患者症状和体征变化等方面逐层分析各药物导致神经系统损害的可能性。结果:临床药师通过合理的分析、判断,给医生提出建议,及时终止了头孢吡肟对患者神经系统的损害。结论:在临床实践中,临床药师可以通过对药物治疗事件的分析与监护,促进合理用药。

Objective： To find out the general regularity of antibiotic encephalopathy caused by cefepime through the case analy- sis, and give reasonable suggestions according to the clinical features. Methods： According to the patient＇s conditions, the clinical pharmacist consulted a large number of literatures and excluded the other factors such as the clinical manifestation of the patient and the used drugs. The clinical pharmacist analyzed the possibility of drug-induced nervous system damage in the aspects of the administration time, dose, drug interactions and changes of symptoms and signs after the drug withdrawal. Results： The clinical pharmacist performed the rational analysis and judgment, provided suggestions for the doctors, and terminated the nervous system damage caused by cefepime in time. Conclusion： In clinical practice, clinical pharmacists analyze drug therapy events and provide pharmaceutical care, which is beneficial to safe and rational drug use.