氯吡格雷联合阿司匹林对进展性缺血性脑卒中患者神经功能及生活能力的影响

Effect of Clopidogrel Combined with Aspirin on Neurological Function and Life Ability of Patients with Progressive Ischemic Stroke

目的探讨氯吡格雷联合阿司匹林对进展性缺血性脑卒中患者神经功能及生活能力的影响。方法选取2013年1月至2014年1月揭西县人民医院收治的86例进展性缺血性脑卒中患者作为研究对象,按随机数字表法将其分为对照组与观察组,各43例。对照组患者给予阿司匹林,观察组患者在对照组基础上采用氯吡格雷进行治疗,比较两组患者的临床疗效、治疗前后神经功能缺损情况、生活能力、超敏C-反应蛋白(HS-CRP)水平及不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后7、14、30 d,两组患者的美国国立卫生研究院卒中量表(NIHSS)评分均明显低于治疗前,日常生活能力量表(ADL)评分均明显高于治疗前,均呈时间依赖性,且观察组患者的NIHSS评分均明显低于对照组,ADL评分均明显高于对照组,差异均有统计学意义(均P<0.05);治疗后7、14、30 d,两组患者的血清Hs-CRP水平均明显低于治疗前,呈时间依赖性,且治疗后14 d、30 d,观察组患者的血清Hs-CRP水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论氯吡格雷联合阿司匹林治疗进展性缺血性脑卒中患者临床效果明显,安全性高,可有效改善患者神经功能缺损情况,减少致残程度,提高其生活能力。

Objective To investigate the effect of clopidogrel combined with aspirin on the neurological function and life ability of patients with progressive ischemic stroke.Methods From January 2013 to January 2014,86 cases of progressive ischemic stroke patients admitted to the Jiexi County People＇s hospital were selected as the research subjects.The patients were divided into the control group and the observation group according to the random number table method,43 cases in each group.The control group were treated with aspirin,clinical observation of patients in the control group based on the use of clopidogrel treatment,compared two groups of patients,before and after the treatment of neural function defect,life skills,super sensitive C-reactive protein（hs CRP） levels and adverse reaction incidence.Results Patients in the observation group the total effective rate of treatment was significantly higher than the control group,the difference was statistically significant（P0.05）;after the treatment of 7 d,14 d,30 d,two groups of the National Institutes of Health Stroke Scale（NIHSS） scores were significantly lower than before treatment,daily life ability scale（ADL） scores were significantly higher than before treatment,showed a time dependent,and the patients in the observation group NIHSS scores were significantly lower than the control group, ADL scores were significantly higher than the control group,the differences were statistically significant（P0.05）;after the treatment of 7 d,14 d,30 d,the serum Hs-CRP level in patients of the two groups were was significantly lower than that before treatment,in a time dependent manner,and after the treatment of 14 d, 30 d, to observe the serum level of Hs-CRP group were significantly lower than the control group,the differences were statistically significant（P0.05）.Conclusion Clopidogrel combined with aspirin in the treatment of progressive ischemic stroke patients with obvious clinical effect, high safety,can effectively improve the neurological function of patients,reduce the degree of disability, improve the ability to live.