儿童与青少年鼻咽癌治疗结束时EBV-DNA拷贝数可预测生存

At the end of the Treatment of Children and Adolescents with Nasopharyngeal Carcinoma EBV-DNA copy number can Predict Survival

目的探讨血浆EBV-DNA拷贝数在儿童与青少年鼻咽癌的诊断意义与预后分析。方法回顾性收集161例儿童与青少年鼻咽癌患者治疗前后的EBV-DNA拷贝数的数值,分析其与总生存、无复发生存、无转移生存的关系。结果161例儿童与青少年鼻咽癌患者中,有69.6%的EBV-DNA为阳性结果。在非Ⅳb期患者中,发现治疗前EBV-DNA表达对总生存(P=0.400)、无复发生存(P=0.659)和无转移生存(P=0.774)差异均无统计学意义。在非Ⅳb期患者中,进行诱导化疗后,阴性组较阳性组有更好的无转移生存(P=0.001)。在非Ⅳb期患者中,进行放疗后,EBV-DNA拷贝数为0与>0比较,无论是总生存(P=0.001)、无复发生存(P<0.001)还是无转移生存(P<0.001),拷贝数为0组均获得更好的生存。结论儿童与青少年鼻咽癌治疗结束时EBV-DNA拷贝数可预测生存。

Objective To explore the plasma EBV-DNA copy number- the diagnostic significance and prognosis of nasopharyngeal carcinoma in children and adolescents.Methods Retrospectively collected 161 cases of child and adolescent patients with nasopharyngeal carcinoma before and after treatment of EBV DNA copy number value, analyzes its and total survival,relapse-free survival,no transfer of the survival of the relationship.Results This study analyzed retrospectively in 161 cases of child and adolescent patients with nasopharyngeal carcinoma,69.6% of EBV DNA for positive results.In patients with non Ⅳ b period,found that the treatment of former EBV DNA expression for total survival（P=0.400）,relapse-free survival（P=0.659）,and no transfer of survival（P=0.774）had no statistical difference. In patients with non Ⅳ b period, carries on the induction chemotherapy,negative than positive group have better without metastasis survival（P=0.001）.In patients with non Ⅳ b period,after radiotherapy,EBV-DNA copy number is equal to zero compared with greater than zero,both overall survival（P=0.001）,relapse-free survival（P0.001）or the transfer of survival（P0.001）,copy number of 0 group has obtained better survival.Conclusion At the end of the treatment of children and adolescents with nasopharyngeal carcinoma EBV-DNA copy number can predict survival.