咽炎清滴丸对急性咽炎大鼠模型抗炎机理研究

Experimental study on effect of Yanyanqing Dropping Pill in acute pharyngitis model rats

目的观察咽炎清滴丸的抗炎作用以及对急性咽炎模型大鼠血清白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α表达的影响。方法采用二甲苯制备小鼠耳肿胀模型、鸡蛋清制备大鼠足趾肿胀模型,考察咽炎清颗粒的抗炎作用;采用15%的氨水复制急性咽炎动物模型,给药后观察咽炎模型大鼠血清白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α含量的变化。结果咽炎清滴丸可以显著对抗二甲苯导致的小鼠耳肿胀,显著抑制鸡蛋清导致的大鼠足趾肿胀,降低急性咽炎模型大鼠血清白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α的含量。结论咽炎清滴丸对急性咽炎模型大鼠具有良好的治疗作用,这是其发挥临床疗效的重要基础。

Objective To investigate the anti -inflammatory action of Yanyanqing Dropping Pill and the expression of IL -1 β,IL -6,TNF -αin acute pharyngitis model rats.Methods Ear swelling model in mice induced by xylene and foot swelling model in rats induced by albumen were chosen to investigate the anti -inflammatory action of Yanyanqing Dropping Pill;Acute pharyngitis model rats induced by 1 5% ammonia were administrated with Yanyanqing Dropping Pill to investigate the change of the contents of IL -1 β,IL -6,TNF -α.Results Yanyanqing Dropping Pill can significantly against the mouse ear swelling caused by dimethylbenzene,can significantly inhibit the toes swelling of rats caused by formaldehyde, and change of the contents of IL -1 β,IL -6,TNF -αin acute pharyngitis model rats.Conclusion Yanyanqing Dropping Pill displayed significant effects on acute pharyngitis model rats.