母代高脂暴露与子代成年期代谢综合征关系动物实验研究进展

Animal Research on the Relationship between Mothers′ Exposure to High Fat Diet and Offspring′s Metabolic Syndrome in the Adulthood

代谢综合征(metabolic syndrome,MS)是一组代谢紊乱症候群,病因尚未明确,肥胖、胰岛素抵抗(insulin resistance,IR)、血脂异常和高血压为其核心组成部分,MS与心血管疾病的发生有关,可增加罹患心血管疾病的风险。母代高脂暴露与子代成年期发生MS之间存在一定相关性,生命早期高脂暴露是成年期发生肥胖、IR、血脂异常、高血压等MS表现的高危因素,母代孕前、孕时和哺乳期各种环境的改变会对子代的代谢状态产生影响,并可长久影响子代成年期的健康状况。孕前及孕期的保健需要特殊关注,以减少MS的发生。综述以上问题动物实验研究方面的新进展。

Metabolic syndrome（MS） is a group of metabolic disorders of unknown etiology, obesity, insulin resistance（IR）, dyslipidemia and hypertension form its core components. MS is related to the incidence of cardiovascular diseases and it may increase the risk of cardiovascular diseases. There is a certain correlation between mothers ′ exposure to high fat diet and offspring′ s MS in the adulthood. Early exposure to high-fat diet could increase the incidence of obesity, IR, dyslipidemia and hypertension in the adulthood, which is high risk factor of MS. Various changes in the environment of progestation, gestation and lactation of mothers will influence the metabolic status of offspring, and can affect the health of offspring for a long time in the adulthood. It′ s time to pay attention to mothers′ health care before conception and during pregnancy particularly in order to reduce the occurrence of MS. The progress of animal research about the relationship is reviewed.