3-磷酸甘油酸脱氢酶在肿瘤中的研究进展

The Effect of Phosphoglycerate Dehydrogenase in Tumors

3-磷酸甘油酸脱氢酶(3-PGDH或PHGDH)是丝氨酸合成途径的关键酶。其编码基因PHGDH位于人类染色体1p12,在一些正常组织中存在高表达,特别对神经系统功能发育有着重要作用。近年研究发现在一些肿瘤细胞中糖酵解途径的部分中间产物进入丝氨酸合成途径,PHGDH酶活性增强、基因出现扩增且蛋白存在高表达,参与调控肿瘤细胞的增殖、凋亡及侵袭等过程。肿瘤细胞代谢方式的改变利于肿瘤的发生发展,研究发现沉默PHGDH可抑制肿瘤细胞增殖并增加细胞凋亡,沉默PHGDH后还可抑制肿瘤细胞侵袭,PHGDH有望成为肿瘤治疗的新靶点。主要从PHGDH基因概述、功能及其在肿瘤发生发展中的作用等方面进行研究进展综述。

Phosphoglycerate dehydrogenase（3-PGDH or PHGDH） is the key enzyme of de novo serine biosynthesis.The PHGDH gene located in human chromosomes 1p12, which is highly expressed in normal tissue, especially for the nervous system function. Recently, it was shown that a part of intermediate metabolites of glycolysis flew to serine biosynthesis. It was found PHGDH gene amplification and over expression in some tumor, PHGDH regulated tumor cell proliferation, apoptosis and invasion. Cell metabolism of tumor is benefit to tumor oncogenesis and progression. The study found that silence PHGDH can inhibit tumor cell proliferation, invasion and increase cell apoptosis. And PHGDH may be a potential treatment target. In this paper, we will review briefly the studies on PHGDH, including structural features,biological function and the genesis and development effect in some tumor.