蔗糖铁注射液致严重风团样皮疹1例

One case of severe wheal rash induced by iron sucrose injection

1例25岁足月轻微贫血孕妇,既往体健,无药物、食物过敏史。患者顺产分娩,生命体征平稳。产后予蔗糖铁注射液改善贫血,约2 h后患者出现全身风团样皮疹,以腹部及四肢为主,伴有瘙痒。给予地塞米松磷酸钠注射液联合葡萄糖酸钙、维生素C抗过敏治疗,1 h后症状缓解。次日再次给予蔗糖铁注射液,输注10 min后风团样皮疹再次出现,症状部位表现同前。立即停用蔗糖铁注射液,予地塞米松磷酸钠注射液联合葡萄糖酸钙、维生素C抗过敏治疗4 d。患者之后无新发皮疹,原皮疹消退,不留痕迹。

One 25-year-old full-term pregnant woman with mild anaemia was healthy without drug and food allergies. She labored naturally with stable vital signs. Iron sucrose injection was given to improve postpartum anemia. About 2 hours, the patient developed systemic wheal rash accompanied with itching, which was mainly on abdomen and limbs. Dexamethasone sodium phosphate injection combined with calcium gluconate and vitamin C were given. One hour later, allergic symptoms relieved. Iron sucrose injection was given again next day, wheal rash appeared 10 minutes after administration. Then iron sucrose injection was immediately stopped and the above anti-allergic medicines were given to the patient. Four days later, the rash disappeared without trace.