慢性肾脏病患者干扰素γ的表达及其临床意义

The clinical study of IFN-γ expression in chronic kidney disease patients

目的检测慢性肾脏病（CKD）患者血清中干扰素γ的表达情况,评价它们在临床实践中的价值。方法收集24例慢性肾脏病患者,根据肾小球滤过率分为CKD 1-2期组、CKD 3-4期组和CKD 5期组,另外收集24例健康成人为对照组。用外周血标本检测四组患者的干扰素γ,并常规检查血尿素氮、肌酐、血脂和肾小球滤过率,并进行对比分析。结果 CKD各期患者与对照组的年龄、性别、体重指数间差异无统计学意义（P〉0.05）。CKD 5期组患者血清干扰素γ的表达均高于对照组、CKD 1-2期组和CKD 3-4期组,差异均有统计学意义（P〈0.05）。在校正了慢性肾脏病患者的年龄、性别、体重指数后,其肾小球滤过率、C反应蛋白和脂联素与血清干扰素γ独立相关。结论慢性肾脏病患者的血清干扰素γ水平明显升高,与肾脏病进展相关,并与肾功能的变化独立相关。

Objective To detect the serum interferon γ（IFN-γ） of patients with chronic kidney disease（CKD）, and investigate the value of IFN-γ in clinical practice. Methods Twenty-four cases of patients with chronic kidney disease were divided into CKD 1~2 stage group, CKD 3~4 stage group, and CKD 5 stage group according to their stage of the disease, and another 24 cases of healthy people were classified to control group. The IFN-γ of peripheral-blood specimens in the four groups were detected, and blood urea nitrogen, creatinine, blood lipids and glomerular filtration rate were detected and compared. Results The age, sex and IBM of patients in the four groups have no significant difference（P〈0.05）. The level of serum IFN-γ in CKD 5 stage group are higher than that in control group, CKD 1~2 stage group and CKD 3~4 stage group,the difference are significant（P〈0.05, respectively）. After revising the age, sex and IBM of CKD patients, the glomerular filtration rate, C-reactive protein, and adiponectin are independently associated with IFN-γ. Conclusion The level of serum IFN-γ in CKD patients are significantly increased. It is related to the progress of renal disease, and is independently associated with the changes of renal function.