炎症因子在危重病人急性深静脉血栓形成和转归中的作用分析

Inflammatory factors as markers for early development and prognosis of acute deep venous thrombosis incritically ill patients

目的探讨炎症因子在危重病人急性深静脉血栓（DVT）病程中的动态变化及与DVT的相关性。方法收集2013年10月至2015年7月在ICU住院期间发生急性DVT患者26例为病例组，分别于发病第1、4、14d检测血清白介素-6（IL-6）、白介素-10（IL-10）、C反应蛋白（CRP）、PCT、ESR水平，同期健康体检者30例为对照组。结果①病例组发病第1、4d血清IL-6、IL-10、CRP水平均高于发病第14d和对照组，差异有统计学意义（P〈0．05）；发病第14d血清IL-6、IL-10、CRP水平与对照组比较差异无统计学意义（P〉0．05）；②病例组三个时间段的PCT、ESR水平均高于对照组，差异有统计学意义（P〈0．05），三个时间段之间PCT、ESR比较差异无统计学意义（P〉0．05）。结论血清IL-6、IL-10、CRP参与危重病人急性DVT的发生与发展。

Objective To evaluate the dynamic changes of inflammatory factors in blood during the development of acute deep venous thrombosis （DVT） and the association between these indices and DVT in critically ill patients. Methods 26 hospitalized patients with acute DVT from ICU from December 2013 to July 2015 were selected as case group. Tested inflammatory factors including IL-6, IL-10, CRP, PCT, ESR on the 1st, 42, 142 day after confirmed diagnosis. 30 healthy examined people were selected as control group. Results The levels of IL-6, IL-10, and CRP on the 1st, 4th day after confirmed diagnosis in case group were higher than those on the 142 day and those in control group; there were no statistically significant differences in the levels of IL-6, IL- 10, and CRP on the 14th day between two groups （P〉0.05）. The levels of PCT, ESR in case group at three time points were significantly higher than those in control group; there were no statistically significant differences in the levels of PCT, ESR among three time points （P〉0.05）. Conclusion Inflammatory factors such as IL-6, IL-10, CPR jointly participate the onset and development of DVT in critically ill patients.