盐酸氨溴索与普米克令舒联合雾化吸入治疗小儿支气管肺炎效果及安全性评价

The efficacy and safety of ambroxol hydrochloride combined with puimicort respules spray inhalation in the treatment of bronchial pneumonia in children

目的探讨盐酸氨溴索与普米克令舒联合雾化吸入治疗小儿支气管肺炎的效果及安全性。方法收集我院2015年1月至2015年11月入院的160例支气管肺炎患儿随机分为两组，对照组患儿给予传统常规治疗，实验组息儿加用盐酸氨溴索与普米克令舒联合雾化吸入治疗，比较两组患儿总体治疗效果评价、呼吸频率与血氧饱和度水平、相关临床指标与安全性等。结果实验组患儿治疗总有效率明显高于对照组，差异有统计学意义（P〈0．05）；实验组患儿治疗后呼吸频率显著低于对照组，血氧饱和度显著高于对照组，差异有统计学意义（P〈0．01）；实验组患儿退热时间、湿哕音消失时间与住院时间显著短于对照组，差异有统计学意义（P〈0．01）；两组患儿不良反应与并发症发生率不存在统计学差异（P〉0．05）。结论盐酸氨溴索与普米克令舒联合雾化吸入治疗小儿支气管肺炎效果显著，且安全性较高，具有借鉴性。

Objective To investigate the efficacy and safety of ambroxol hydrochloride combined with pulmicort respules spray inhalation in the treatment of bronchial pneumonia in children. Methods 160 children with bronchial pneumonia admitted in our hospital from January 2015 to November 2015 were randomly divided into two groups. Control group was treated with conventional treatment, and experimental group was treated with ambroxol hydrochloride and pulmicort respules spray inhalation. The overall treatment effect, respiratory rate, oxyhemoglobin saturation, correlated clinical indexes and safety in two groups were compared. Results The overall effective rate of experimental group was significantly higher than that of control group, with statistically significant difference （P〈0.05）. Respiratory rate in experimental group was significantly lower than that in control group, oxyhemoglobin saturation was significantly higher than that in control group, with statistically significant differences （P〈0.01）. Fever subsidence time, moist tales disappearing time, hospital stay in experimental group were significantly shorter than those in control group, with statistically significant differences （P〈0.01）. There were no statistically significant differences in the incidence of adverse reactions and complications between two group （P〉0.05）. Conclusion Ambroxol hydrochloride combined with pulmicort respules spray inhalation has significant effect in the treatment of bronchial pneumonia in children, with high safety, of reference in clinical practice.