11～13^(+6)周中孕早期胎儿心脏畸形和染色体异常与NT值之间的相关性研究

A correlation study on abnormal fetal heart and chromosomal abnormalities and NT value in the early stage of 11W-13^(+6)W

目的探讨11~13^(+6)周中孕期早期NT值与胎儿心脏畸形和染色体异常之间的相关性。方法回顾性分析2012年1月至2015年3月怀孕11~13^(+6)周的3218例孕妇临床资料,根据NT值将孕妇分为≥3.5mm组(149例)和<3.5mm组(3069例),对两组胎儿于11~13^(+6)周检测NT值,分析NT值与胎儿心脏畸形和染色体异常的相关性。结果 NT值≥3.5mm组的胎儿心脏畸形和染色体异常及两者兼异常的概率明显高于NT值<3.5mm组(P<0.05)。结论 NT值异常与胎儿心脏畸形和染色体异常之间有明显的相关性,NT值检测对早期诊断胎儿心脏畸形和染色体异常有重要的临床使用价值。

Objective To investigate the correlation between NT value and abnormal fetal heart and chromosomal abnormalities in the early stage of 11-13＋6W.Method The clinical data of 3218 cases of pregnant with 11W-13＋6Wfrom January 2012 to March 2015 were retrospectively analyzed and were divided into NT values≥3.5mm group（149cases）and NT values〈 3.5mm group（3069cases）.The values of fetuses of two groups were detected with 11-13＋6Wand the correlation of NT value and abnormal fetal heart and chromosomal abnormalities were analyzed.Results The probability of abnormal fetal heart and chromosomal abnormalities or the probability of both in the NT values≥3.5mm group was obviously higher than that in the NT values 〈3.5mm group（P〈0.05.Conclusions There is a significant correlation between NT value anomaly and abnormal fetal heart and chromosomal abnormalities,and the value of NT detection of early diagnosis of fetal cardiac malformations and chromosomal abnormalities has important clinical value.