来氟米特联合甲氨蝶呤治疗类风湿关节炎的疗效评价

The clinical efficacy of leflunomide combined with methotrexate in Rheumatoid arthritis

目的：评价来氟米特联合甲氨蝶呤对类风湿关节炎的治疗效果和安全性。方法：选取2014年3月~2015年12月于我院风湿免疫科就诊的类风湿关节炎患者100例,随机均分为联合组和单纯组,联合组接受来氟米特合甲氨蝶呤治疗,单纯组只接受甲氨蝶呤单独治疗;治疗结束后比较两组临床症状改善情况,血沉、炎症相关因子改变指标等,并分析联合用药的安全性。结果：联合组临床症状和血清学指标改善情况均较单纯组明显（P〈0.05）,药物副反应两组无明显差异（P〉0.05）。结论：联合运用来氟米特和甲氨蝶呤治疗类风湿关节炎疗效确切安全性高,临床应用时结合患者的疾病状况使用。

Objective：To evaluate the clinical efficacy and safety of leflunomide combined with methotrexate in rheumatoid arthritis.Methods：100 rheumatoid arthritis patients were collected,randomize into single group and combined group,both received methotrexate treat,while on this basis,combined group received methotrexate treat; the clinical symptoms improvement,ESR,inflammation-related factors were compared after treat,analyzed the security of combination therapy. Results：The clinical symptoms improvement and serology improved significantly in the combined group than single group（P 〈0.05）; there was no difference in the adverse drug reactions（P 〈0.05）. Conclusion：Leflunomide and methotrexate combination therapy in rheumatoid arthritis is effective,combine with the disease condition of the patient to medicate.