核苷酸切除修复系统基因多态性与淋巴造血系统肿瘤药物治疗反应的研究进展

Association Between Polymorphisms of Nucleotide Excision Repair Genes and Drug Response of Lymphoid Hematopoietic Malignancies

核苷酸切除修复途径是细胞内最主要、最灵活的DNA修复方式。单核苷酸多态性(single nucleotide polymorphisms,SNPs)是人类第三代分子遗传标志物,反映了个体表型、疾病易感性以及对药物、环境等影响因素反应的差异。淋巴造血系统肿瘤是一种多基因遗传疾病,涉及到多个遗传易感基因的相互作用。全文就NER基因多态性与淋巴造血系统肿瘤药物反应性密切关联的相关基因进展作一综述。

Nucleotide excision repair（NER） is the main and most flexible DNA repair mode in the cells. Single nucleotide polymorphisms（SNPs） are the third generation of human molecular genetic markers,which reflects the diversity in individual phenotype,disease susceptibility and drug response and other environmental factors. Lymphoid hematopoietic malignancies are multi-gene genetic diseases,in which multiple genetic susceptibility genes are involved. This review summaraized the progress on association between polymorphisms NER genes and drug responsiveness of lymphoid hematopoietic malignancies.