睾丸生殖细胞肿瘤遗传易感性研究进展

Research Progress on Genetic Susceptibility to Testicular Germ Cell Tumor

睾丸生殖细胞肿瘤是严重危害青壮年男性身体健康的疾病,目前其病因尚未探明;睾丸生殖细胞肿瘤发病年龄较早、没有明确环境致癌因素、存在明显种族发病差异、有较高遗传度;因此从人群肿瘤遗传易感性角度着手研究,更有助于探究发现其病因,为筛查、诊断、预防及治疗提供依据。利用基于单核苷酸多态性的全基因组关联研究等研究方法,近来国外发现了多个睾丸生殖细胞肿瘤发病相关基因,使睾丸生殖细胞肿瘤的遗传易感性研究取得了重要的进展。

Testicular germ cell tumors（TGCTs） is a disease that seriously endanger the health of young male,and its etiology has not been proven. TGCTs shows an early age of onset,undefined environmental carcinogens,obvious differences in the incidence of race,and high heritability.Therefore,from the perspective of population,genetic susceptibility to TGCTs will be more benefit to exploring its etiology,and provide evidence for screening,diagnosis,prevention and treatment. In recent years,genome-wide association studies（GWAS） and other research methods based on single nucleotide polymorphisms（SNPs）,a number of TGCTs associated genes have been found,which makes the research of genetic susceptibility of TGCTs achieve significant progress. The related content will be reviewed herein.