头颅磁共振成像在克雅氏病监测中的特点分析

Characteristics of cerebral magnetic resonance imaging in Creutzfeldt-Jakob disease surveillance in China

目的了解头颅磁共振成像(magnetic resonance imaging,MRI)扫描在克雅氏病(Creutzfeldt-Jakob disease,CJD)监测及诊断中的重要作用。方法对2013年以来我国CJD监测网络中的MRI数据进行分析。结果通过数据分析发现,95.93%(377/393)的散发型克雅氏病(sporadic Creutzfeldt-Jakob disease,s CJD)临床诊断病例进行过头颅MRI扫描。弥散加权像(diffusion-weight imaging,DWI)显示对称或不对称性"缎带征"是s CJD临床诊断中最常见的MRI特征性改变,而质子密度相双侧丘脑后结节部高信号的病例数相对较少。结论头颅MRI扫描检测对s CJD的临床诊断具有重要的作用。MRI扫描结果纳入到CJD监测网络后,将进一步完善我国CJD监测体系,增加对s CJD临床诊断的准确性。

Objective To understand the role of cerebral magnetic resonance imaging（ MRI） in the surveillance and diagnosis of Creutzfeldt-Jakob disease（ CJD） in China. Methods The MRI data from China CJD surveillance network since2013 was analyzed. Results According to the analysis of the latest 3-year cerebral MRI data,cerebral MRI was performed for 95. 2% of probable s CJD cases（ 374 /393）. The most frequently observed characteristic change of MRI in probable s CJD cases was symmetry or asymmetry ribbon in Diffusion Weighted Imaging,while protono-density-weighted exhibited high signal in the bilateral thalamus posterior nodules was rarely observed in probable s CJD cases. Conclusion Cerebral MRI plays an important role in the diagnosis of s CJD. Integration of MRI with CJD surveillance network would further improve the CJD surveillance system and the diagnostic of s CJD in China.