中药对肠易激综合征脑肠肽影响的药理研究进展

Pharmacology research advance in the effect of traditional Chinese medicine on brain-gut peptide in irritable bowel syndrome

肠易激综合征是临床常见的以腹部不适并伴排便改变为特征的功能紊乱性胃肠道疾病。研究表明,肠易激综合征与脑肠肽的变化密切相关。近年来,中药治疗该病已取得一些可靠性成果。本文从血管活性肠肽、P物质和降钙素基因相关肽、5-羟色胺、促肾上腺皮质激素释放因子和生长抑素等脑肠肽的角度系统阐述中药治疗肠易激综合征的药理研究进展。

Irritable bowel syndrome is a functional disorder of gastrointestinal diseases, characterized with abdominal discomfort and bowel movement change, which have been very common. Studies have shown that changes of brain-gut peptide are closely associated with IBS. In recent years, some reliable results were obtained from traditional Chinese medicine treating the disease. The article systematically elaborated the advances in pharmacology research on traditional Chinese medicine for irritable bowel syndrome from the following： vasoactive intestinal peptide, substance P, calcitonin gene related peptide, 5-hydroxytrypamine, corticotrophin releasing factor, value of somatostatin and so on.