摘要
目的 探讨沿海地区单纯性肥胖患者骨成型蛋白(BMP)-4表达水平及其与体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)等的相关性.方法 采用ELISA方法检测了正常对照组和单纯性肥胖各44例血浆BMP-4水平,并采用Logistic回归分析了BMP-4水平与BMI、WHR、血脂、糖化血红蛋白(HbA1c)、FBG、FINS和HOMA-IR等的相关性.结果 单纯性肥胖患者BMP-4水平(10.98±6.76)明显高于对照组(5.12±3.01),差异有统计学意义(P<0.01);Logistic回归线性相关分析表明,BMP-4与三酰甘油(TG)、BMI、FINS和HOMA-IR呈明显正相关(r值分别为0.421、0.425、0.473、0.396,均P<0.01).以BMP-4为因变量,性别、年龄、WHR、BMI、TG、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、HbA1c、FBG、FINS和HOMA-IR为自变量,进行多元线性逐步回归分析,结果表明FINS是影响BMP-4的相关因素.二项Logistic回归分析表明:控制性别、年龄、WHR、TC、TG、HDL、LDL、HbA1c、FBG和FINS后BMP-4水平与单纯性肥胖仍呈显著相关.结论 BMP-4水平的改变与肥胖患者的代谢紊乱有关,并可能参与了单纯性肥胖的发生和发展.
Objective To investigate the expression levels of bone morphogenetic protein (BMP-4) in the people with simple obesity in coastal areas and its relationship with the BMP-4 expression,body mass index (BMI),waist hip ratio (WHR),fasting blood glucose (FBG),fasting insulin (FINS) and HOMA-IR.Plasma BMP-4 levels of 40 cases with simple obesity and the controls were respectively detected by ELISA.And then,the association of BMP-4 levels with BMI,WHR,HOMA-IR,blood lipids,HbA1c,FBG,FINS and HOMAIR were analyzed by Logistic regression.Methods The BMP-4 levels in the patients with simple obesity (10.98 ±6.76) were significantly higher than those of the control group (5.12 ±3.01),with statistical significance (P 〈 0.01).Logistic regression analysis indicated that the BMP-4 levels were positively correlated with the levels of triglyceride(TG),BMI,FINS and HOMA-IR,with the r value being respectively 0.421,0.425,0.473 and 0.396 (P 〈 0.01).Multiple regression analysis was made with BMP-4 as the function,sex,age,WHR,BMI,TG,total cholesterol (TC),low density lipid (LDL),high density lipid (HDL),HbA1c,FBG,FINS and BMP-4 as the independent variables.Results indicated that the FINS level was a related factor affecting the BMP-4 level.Binomial Logistic regression analysis indicated that the BMP-4 level was still significantly correlated with simple obesity,following tight control of such factors as sex,age,WHR,TG,TC,LDL,HDL,HbA1c,FBG and FINS.Conclusions The changes in the BMP-4 levels were associated with metabolism disorder of the patients with simple obesity,which might be involved in the pathogenesis of simple obesity.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2016年第2期141-143,共3页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
单纯性肥胖
骨成型蛋白-4
胰岛素抵抗
Simple obesity
Bone morphogenetic protein-4
Insulin resistance