鲑鱼降钙素联合碳酸钙D3片治疗绝经妇女桡骨远端骨折的疗效观察

Clinical observation of salmon calcitonin combined with calcium carbonate and vitamin D3 in treatment of distal radius fracture in postmenopausal women

目的评估鲑鱼降钙素鼻喷剂联合碳酸钙D3片治疗绝经妇女桡骨远端骨折的临床疗效。方法选取2012年12月—2014年12月在陕西省核工业二一五医院骨科接受掌侧钢板内固定的桡骨远端骨折绝经妇女59例,所有患者随机分为对照组(26例)和治疗组(33例)。对照组口服碳酸钙D3片,1片/次,1次/d。治疗组在对照组治疗基础上给予鲑鱼降钙素鼻喷剂,200 IU/d。两组均连续治疗3个月,并随访6个月。比较视觉模拟评分(VAS)、骨密度值、腕关节功能。结果治疗3 d、1个月、3个月、随访6个月,两组患者的VAS评分均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗1、3个月后,治疗组患者的VAS评分改善程度明显优于同期对照组,两组比较差异有统计学意义(P<0.05)。治疗3个月、随访6个月,治疗组的骨密度值均较治疗前显著增高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者的骨密度值改善程度明显优于同期对照组,两组比较差异具有统计学意义(P<0.05)。而对照组的几乎没有变化。治疗后,对照组和治疗组患者腕关节功能评分优良率分别为61.5%、87.9%,两组优良率比较差异具有统计学意义(P<0.01)。结论鲑鱼降钙素联合碳酸钙D3片治疗绝经妇女桡骨远端骨折具有较好的疗效,能够增加骨密度,促进腕关节功能恢复,具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy of Salmon Calcitonin Nasal Spray combined with Calcium Carbonate and Vitamin D3 Tablets in treatment of distal radius fracture in postmenopausal women. Methods Postmenopausal women（59 cases） with distal radius fracture in Department of Bone of No. 215 Hospital of Shaanxi Nuclear Industry from December 2012 to December 2014 were randomly divided into control（26 cases） and treatment（33 cases） groups. The patients in the control group were po administered with Calcium Carbonate and Vitamin D3 Tablets, 1 tablet/time, once daily. The patients in the treatment group were given Salmon Calcitonin Nasal Spray on the basis of the control group, 200 IU/d. The patients in two groups were treated for 3 weeks, and followed up for 6 months. VAS score, bone mineral density, and wrist joints function were compared between two groups. Results After treatment for 3 d, 1 moth, 3 months, and follow-up for 6 months, VAS score in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment for 1 moth and 3 months, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment for 3 months and follow-up for 6 months, bone mineral densities in the treatment groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. But there was no change in the control group. After treatment, the excellent rates of wrist joints function in the control and treatment groups were 61.5% and 87.9%, respectively, and there were differences between two groups（P〈0.01）. Conclusion Salmon Calcitonin Nasal Spray combined with Calcium Carbonate and Vitamin D3 Tablets has clinical curative effect in treatment of distal radius fracture in postmenopausal women, can relieve pain, increase bone density, and promote the wrist joint function recovery, which has a certain clinical application value.