摘要
小檗碱是从黄连等植物中提取的一种异喹啉类生物碱,作为传统的抗炎、抑菌药物在临床应用已久。近年来研究发现其具有调脂作用,可通过调节肠道菌群结构、影响胆汁酸的合成与代谢、上调低密度脂蛋白受体(LDLR)的表达、激活内脏脂肪组织相关基因的表达、升高血清脂联素的表达、激活腺苷酸活化蛋白激酶(AMPK)途径、改善胰岛素抵抗等多个作用靶点发挥调脂作用,主要针对小檗碱的调脂作用及其机制进行综述。
Berberine is an isoquinoline alkaloid isolated from Coptis chinensis, and it is applied widely in clinic as a traditional anti-inflammatory and antibacterial drug for a long time. In recent years, it has been discovered that berberine still has lipid-regulating effects. Berberine plays the role of lipid-regulating by adjusting the structure of intestinal flora, influencing the synthesis and metabolism of bile acid, up-regulating the expression of low density lipoprotein receptor（LDLR）, activating the expression of visceral adipose tissue related genes, elevating the expression of adiponectin, activating AMP-activated protein kinase（AMPK） pathways, and improving insulin resistance. This paper mainly summarizes the lipid-regulating function of berberine and its mechanisms of action.
出处
《现代药物与临床》
CAS
2016年第5期727-730,共4页
Drugs & Clinic
基金
"重大新药创制"科技重大专项(2012ZX09303-008-001)
2010年国家临床重点专科建设项目
关键词
小檗碱
调脂作用
作用机制
berberine
lipid-regulating function
mechanism of action
