不同输液速度预防静脉输注盐酸左氧氟沙星所致静脉炎的效果观察

Effect of different infusion speeds on prevention phlebitis caused by levofloxacin hydrochloride

目的探讨不同输液速度预防静脉输注盐酸左氧氟沙星所致静脉炎的效果。方法将160例需要静脉输注盐酸左氧氟沙星的患者按简单数字表法随机分为观察组（40例）、对照组1（40例）、对照组2（40例）、对照组3（40例）。观察组及对照组1、2、3组输液速度分别为：61~70 gtt/min、30~40 gtt/min、41~50 gtt/min和51~60 gtt/min。观察4组患者静脉炎发生情况。结果 4组患者静脉炎发生情况比较,P〈0.05,差异具有统计学意义,其中观察组患者静脉炎发生率明显低于照组1、对照组2、对照组3,组间比较,均P〈0.05,差异具有统计学意义;对照组1、对照组2及对照组3,3组组间比较,均P〉0.05,差异无统计学意义。结论采用稍快输液速度（61~70 gtt/min）可以有效预防和减少盐酸左氧氟沙星静脉滴注所致静脉刺激症状,降低静脉炎的发生率。

Objective To explore the effect of different infusion speeds on prevention phlebitis caused by lavofloxacin hydrochloride. Methods One hundred and sixty patients treated with intravenous infusion of lavofloxacin hydrochloride were randomized by simple digital table into one observation group and three control groups with 40 in each group. The infusion velocities in the observation group and other three control groups were 61 ~ 70 gtt / min, 30 ~ 40 gtt / min, 41 ~ 50 gtt / min and 51 to 60 gtt / min,respectively. The incurrence rate of phlebitis was compared among the four groups. Results The incidence rate of phlebitis in the observation group was significantly lower than that of the respective control group（all P〈 0.05）. There were no differences among the three control groups in terms of phlebitis rate. Conclusion Intravenous infusion of lavofloxacin hydrochloride at the infusion velocity of61 ~ 70 gtt / min can reduce the incidence of phlebitis.