甲钴胺口服与维生素B_(12)肌注治疗巨幼红细胞性贫血的临床疗效比较

The Comparison Study on Mecobalamin Oral and Intramuscular Injection of Vitamin B12 in the Treatment of Megaloblastic Anemia

目的对比分析甲钴胺和维生素B_(12)治疗巨幼红细胞性贫血的效果。方法选取我院治疗收治的150例巨幼红细胞性贫血患者为研究病例,随机分为研究组75例(口服甲钴胺治疗)和对照组75例(肌注维生素B_(12)治疗),跟踪随访,观察比较两组的疗效。结果治疗后两组血红蛋白含量、血小板高于治疗前,红细胞平均体积低于治疗前,差异有统计学意义(P<0.05);在相同时间点,两组血常规各项指标差异无统计学意义(P>0.05)。结论口服甲钴胺治疗巨幼红细胞性贫血的效果与肌注维生素B_(12)的效果均较好。

Objective To compare the effect of mecobalamin oral and intramuscular injection of vitamin B12 in the treatment of megaloblastic anemia. Methods 150 cases with megaloblastic anemia were selected as the research cases in our hospital. They were randomly divided into study group（mecobalamin oral treatment,n=75） and control group（intramuscular injection of vitamin B12 treatment,n=75）,a follow-up was made and the curative effect was observed and compared between the two groups. Results After treatment,the hemoglobin and platelets were significantly higher than that before treatment in two groups,the mean corpuscular volume was significantly lower than that before treatment（P〈0.05）,the difference was significant. At the same time,there were no significant differences in blood routine indicators in two groups（P〉0.05）. Conclusion The effect of mecobalamin oral treatment is better than intramuscular injection of vitamin B12 for the treatment of megaloblastic anemia.