瑞舒伐他汀钙对飞行人员代谢综合征患者胰岛素抵抗的影响

Effects of Rosuvastatin Calcium on insulin resistance of the flying personnel with metabolic syndrome

目的 探讨瑞舒伐他汀钙对飞行人员代谢综合征（metabolic syndrome,MS）患者胰岛素抵抗（insulin resistance,IR）的影响. 方法 飞行人员代谢综合征患者65例,按照双盲和对照的方法分为A组（32例）、B组（33例）.A组给予瑞舒伐他汀钙10mg/d,B组给予安慰剂10mg/d,均与晚饭同服.对比观察治疗前与治疗4周后两组患者平衡模式测算胰岛素抵抗指数（homeostasis model assessment insulin resistance index,HOMA-IR）变化和药物的不良反应情况. 结果 A组和B组患者治疗前空腹胰岛素（fasting insulin,FINS）、空腹血糖（fasting blood glucose,FBG）、HOMA-IR比较差异无统计学意义（P＞0.05）;治疗4周后,两组患者FINS、FBG、HOMA-IR比较,A组较B组降低明显（t=2.895～3.231,P＜0.01）,体质指数（body mass index,BMI）差异无统计学意义（P＞0.05）.两组患者治疗后组内比较,HOMA-IR、FBG也明显下降（t=4.228～8.846,P＜0.05）,BMI差异无统计学意义（P＞0.05）.两组患者治疗前后FINS、FBG与HOMA-IR成正相关（r=0.436～0.982,P＜0.05）,与BMI无相关性（P＞0.05）.两组患者对治疗均耐受性良好,谷丙转氨酶、肌酐、肌酸激酶治疗前后差异无统计学意义（P＞0.05）. 结论 瑞舒伐他汀钙有改善飞行人员代谢综合征患者IR的作用.建议飞行人员建立健康的生活方式,必要时服用瑞舒伐他汀钙来有效改善胰岛素抵抗.

Objective To investigate the effects of Rosuvastatin Calcium on insulin resistance （IR） in the flying personnel with metabolic syndrome （MS）.Methods Sixty-five cases of flying personnel with metabolic syndrome were assigned to group A （32 cases） and group B （33 cases） according to double blind and control method.Group A was administered with Rosuvastatin Calcium （10 mg/d） while group B was ingested by placebo （10 mg/d） with dinner.Homeostasis model assessment insulin resistance index （HOMA-IR） and drug adverse reactions of 2 groups were observed and compared before and 4 weeks after the treatment.Results There was no significant difference in the level of HOMA-IR,fasting insulin （FINS） and fasting blood glucose （FBG） between group A and group B before treatment （P〉0.05）.After 4-week treatment,HOMA-IR,FINS and FBG of group A was significantly lower than that of group B （t=2.895-3.231,P〈0.01）.But there was no significant difference in body mass index （BMI） （P〉 0.05）.There was significant difference of HOMA-IR,FBG in each group after treatment （t=4.228-8.846,P〈0.05） and no significant difference in BMI （P〉0.05）.FINS and FBG were positively correlated with HOMA IR （r=0.436-0.982,P〈0.05）,but BMI had no correlation with HOMA-IR （P〉0.05）.Flying personnel of group A and group B were well tolerated to the treatments of Rosuvastatin Calcium.Glutamic-pyruvic transaminase,creatinine and creatine kinase had no significant difference by the treatment （P〉0.05）.Conclusions Rosuvastatin Calcium could improve IR in the flying personnel with MS.It is suggested that healthy lifestyle should be build and Rosuvastatin Calcium would be taken for the flying personnel with MS to effectively improve their IR if necessary.