白芍不同炮制品芍药苷含量测定及其镇痛作用的比较研究

Determination of Paeoniflorin in Different Processed Products of Baishao(Radix Paeoniae Alba) and Comparison of Their Analgesic Effect

目的:测定白芍不同炮制品中芍药苷的含量并比较其镇痛作用。方法:采用薄层扫描法对芍药生品、酒制、麸炒、醋制及炒黄品进行芍药苷含量测定,同时采用小鼠扭体法进行镇痛实验。结果:白芍不同炮制品中芍药苷含量均低于生品,而镇痛作用均强于生品。结论:白芍不同炮制品的镇痛作用与芍药苷含量没有相关性。

Objective： To study the influence of different processing methods on Paoniflorin content and analgesic effect of Radix Paeoniae alba. Methods： TLC method was adopted to determine the paeoniflorin content in Radix Paeoniae alba. The analgesic effect was assessed by writhing test in mice. Results： The paeoniflorin content in Radixpaeoniae alba without processing was the highest,that was higher than that of the other processed products; but the products processed by different methods showed stronger analgesic effect than that without processing. Conclusion： There was no relationship between the paeoniflorin content and the analgesic effect in the different processed products of Radix Paeoniae alba.