持续和间歇低氧运动对肥胖大鼠体重及相关代谢指标的影响

The effect of continuous and intermittent hypoxic exercise on body composition and serum index in obese rats

在常氧和低氧(常氧安静组、间歇常氧运动组、持续常氧运动组、低氧安静组、间歇低氧运动组和持续低氧运动组)环境中,建立肥胖造模SD大鼠暴露和水槽游泳运动方案。游泳训练持续8周,每周5d,每天定时称测大鼠24h内饲料消耗量;训练结束后处死大鼠,测定体重、体长及内脏脂肪重,并采血检测血脂、血糖、胰岛素和瘦素。结果表明:常氧运动后肥胖大鼠摄食量增加,而与其相对的低氧运动大鼠摄食量却减少;常氧和低氧运动对肥胖大鼠均有很好的减重作用,低氧运动较常氧运动作用更加明显,而以持续低氧运动效果最佳;常氧、低氧运动和单纯低氧均引起肥胖大鼠胆固醇、三酰甘油、低密度脂蛋白、血糖和胰岛素降低或呈降低趋势,而高密度脂蛋白和瘦素升高或呈升高趋势;大鼠内脏脂肪积累与体重变化一致。

To study the effect of continuous and intermittent hypoxic exercise on body composition,blood lipids,glucose,insulin and leptin in obese rats,the obese model rats were randomly divided into 6groups：normoxic sedentary exposure,intermittent normoxic exercise,continuous normoxic exercise,hypoxic sedentary exposure,intermittent hypoxic exercise and continuous hypoxic exercise.Under normoxic and hypoxic conditions,rats were exposed and trained by swimming exercise for 8weeks,5days per week.Diet consumption of rats was measured every day.After training,body weight and stem length of rats were measured.Their blood and visceral fat were collected.Blood lipids,glucose,insulin and leptin were determined.Normoxic exercise increased diet of obese rats,but hypoxic exercise decreased it.Normoxic and hypoxic exercise had weight relief for obese rats.Comparing with normoxic exercise,hypoxic exercise showed more significant effect.Continuous hypoxic exercise was most significant in all groups.Normoxic exercise,hypoxic exercise and hypoxic condition decreased blood TC,TG,LDL-C,glucose and insulin in rats or showed trend,increased HDL-C and leptin or showed trend.Hypoxic exercise improved blood lipids and glucose metabolism,decreased body weight of rats.Continuous normoxic exercise was better than intermittent normoxic exercise.