摘要
目的探讨调强放射治疗配合化疗治疗晚期胰腺癌的临床效果。方法选取2013年1月至2014年12月间收治的56例晚期胰腺癌患者,采用简单随机抽样法分为观察组和对照组,每组28例。两组患者均给予吉西他滨化疗,观察组患者在此基础上加用调强放射治疗。比较两组患者的治疗有效率、不良反应发生率和生存率。结果观察组患者治疗有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组患者无进展生存时间和总生存时间均高于对照组,差异均有统计学意义(均P<0.05)。观察组患者不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论调强放射治疗配合化疗治疗晚期胰腺癌临床疗效显著,可以有效地增加患者的生存时间,具有临床应用价值。
Objective To investigate the clinical effects of intensity modulated radiation therapy combine with chemotherapy in the treatment of advanced pancreatic cancer. Methods From January 2011 to December 2014 in Wuhan Puren Hospital,56 patients with advanced pancreatic cancer were randomly divided into observation group and control group,28 cases in each group. Patients in two groups were treated with gemcitabine,and the patients in observation group were treated by intensity modulated radiation therapy additionally. Clinical effective,adverse reaction rate and survival rate of two groups were compared. Results The effective rate of the observation group was significantly higher than that of the control group,with statistical difference（ P〈 0. 05）. The progression free survival and overall survival in the observation group were significantly higher than those in the control group,with statistical difference（ P 〈0. 05）. There was no significant difference of adverse reactions rate between two groups（ P〉 0. 05）. Conclusion The clinical curative effect of intensity modulated radiation therapy combined with chemotherapy in treatment of advanced pancreatic cancer can effectively increase the survival time of patients,which is worthy of clinical application.
出处
《中国肿瘤临床与康复》
2016年第6期668-671,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胰腺肿瘤
调强放射治疗
药物疗法
治疗结果
Pancreatic cancer
Intensity modulated radiation therapy
Drug therapy
Treatment outcome
