血清内脏脂肪素与糖尿病周围神经病变的相关性研究

The relationship between serum visfatin and type 2 diabetic peripheral neuropathy

目的测定糖尿病周围神经病变(DPN)患者血清内脏脂肪素(Visfatin)水平,探讨Visfatin与DPN的相关性。方法选取我科住院的T2DM患者90例,分为T2DM合并周围神经病变组(DPN)58例,T2DM不合并周围神经病变组(Non-DPN)32例。另选正常对照组(NC)30名。测定各组FPG、TG、TC、LDL-C、HDL-C,Fins、Visfatin及肝、肾功能;稳态模型评估胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。结果 Visfatin水平在NC、Non-DPN和DPN组逐渐升高[(141.3±57.5)vs(242.3±58.0)vs(350.1±59.8)pg/ml](P<0.05)。Visfatin水平与病程、WHR、FPG、HbA_1c、TG、胱抑素C(Cys-C)、UAER呈正相关(r分别为0.323、0.128、0.449、0.325、0.172、0.327、0.329,P<0.05),与HOMA-β呈负相关(r=-0.497,P<0.01);Logistic回归分析显示,Visfatin是影响DPN发生的独立危险因素。结论血清Visfatin水平的升高可能与DPN有关。

Objective To detect the serum visfatin levels in type 2 diabetes（T2DM） patients with or without peripheral neuropathy,and to explore the relationship between visfatin and diabetic peripheral neuropathy（DPN）.Methods 90 patients with T2 DM were divided into T2 DM with DPN group（DPN group,n = 58） and without DPN group（Non-DPN group,n = 32）.30 healthy people were selected as normal controls（NO.Biochemical parameters were measured,including fasting blood glucose（FPG）,triglyceride（TG）,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,and hemoglobin Alc（HbA_1c）,fasting insulin（FIns） and liver and kidney function.The homeostasis model assessment（HOMA） was used to estimate insulin resistance index（IR）and islet β-cell function（HOMA-β）.Serum visfatin levels were determined by method of ELISA.Results DPN group had the highest levels of serum visfatin,followed by Non-DPN group,and then NC group[（141.3±57.5） to（242.3 ± 58.0） vs（350.1 ± 59.8）pg/ml]（P〈0.05）.Pearson relation analysis showed that serum visfatin level was positively correlated with diabetic duration,WHR,FPG,HbA_1c,Cys-C,and UAER（r = 0.323,0.128,0.449,0.325,0.172,0.327,and 0.329,respectively,P〈0.05）,and negatively correlated with HOMA-β（r=- 0..497,P〈0.01）.Logistic regression analysis showed that serum visfatin was independent risk factors for DPN in patients with T2 DM.Conclusion The high levels of serum visfatin may be related to the process of DPN.