升高的血清Nexilin是缺血性脑卒中的独立危险因素

High serum Nexilin level is an independent risk factor for ischemic stroke

目的 探讨缺血性脑卒中患者检测血清Nexilin水平的临床价值。方法 连续收集急性缺血性脑卒中患者185例〔男120例,女65例,平均年龄（64.6±9.3）岁〕,对照组215例〔男120例,女95例,平均年龄（64.7±9.0）岁〕。采用ELISA方法检测血清Nexilin含量。结果 与对照组比较,急性缺血性脑卒中患者血清Nexilin含量明显升高〔0.81（0.51~1.33）ng/ml vs.0.15（0.11~0.26）ng/ml,P〈0.001〕,以Nexilin≥0.80 ng/ml（对照组95百分位数）作为升高标准,缺血性脑卒中患者高血清Nexilin比率明显高于对照组（50.81%vs.5.58%,P〈0.001）。多因素回归分析显示升高的血清Nexilin水平是缺血性脑卒中的独立危险因素。结论 急性缺血性脑卒中患者血清Nexilin水平明显升高,升高的血清Nexilin是缺血性脑卒中的独立危险因素。

Objective To detect serum Nexilin concentrations and to explore the potential clinical value in patients with ischemic stroke. Methods A total of 185 patients with acute ischemic stroke and 215 control subjects were involved. Serum Nexilin concentration was detected by enzyme-linked immunosorhent assay. Results Compared with controls, ischemic stroke patients had significantly higher nexilin concentration [ 0. 81 （0. 51-1.33 ） ng/ml vs. 0. 15 （0. 11 - 0. 26） ng/ml, P〈0. 001 ]. When Nexilin 0. 80 ng/ml （95 % of controls） was de- fined as elevation, the percentage of subjects with elevated Nexilin level was significantly higher in ischemic stroke group compared to that in control group （50. 81% vs. 5.58% ,P〈0. 001 ）. High serum level of Nexilin was an independent risk factor for ischemic stroke. Conclusions Ischemie stroke patients have significantly elevated serum Nexilin levels, and serum Nexilin is a potential useful biomarker for ischemic stroke.