退变性腰椎滑脱症患者髓核和血清中AGEs、RAGE、sRAGE表达变化的相关性及与预后的关系

The changes of AGEs,RAGE,sRAGE in nucleus pulposus and serum of patients with degenerative lumbar spondylolisthesis as well as their correlation with prognosis

目的探究退变性腰椎滑脱症患者髓核和血清中AGEs、RAGE、sRAGE表达变化的相关性研究及其预后的关系。方法随机选取80例退变性腰椎滑脱症患者作为试验组,选取80名健康志愿者作为对照组。对患者髓核和血清中治疗前后的AGEs,RAGE、sRAGE表达变化水平进行统计,分析退变性腰椎滑脱症患者髓核和血清中AGEs,RAGE、sRAGE表达变化的相关性及其预后的关系。结果退变性腰椎滑脱症患者髓核和血清中AGEs,RAGE水平显著增加(P<0.05),而sRAGE水平显著降低(P<0.05);患者的髓核和血清中AGEs和RAGE表达变化水平与退变性腰椎滑脱症水平呈正相关(P<0.05),sRAGE水平与退变性腰椎滑脱症水平呈负相关(P<0.05);患者的髓核中AGEs,RAGE和sRAGE表达变化水平与血清中水平呈正相关(P<0.05)。结论退变性腰椎滑脱症患者髓核和血清中AGEs,RAGE与病症呈正相关,sRAGE表达变化水平与病症呈负相关。髓核和血清的AGEs、RAGE和sRAGE水平呈正相关。

Objective To observe the changes of advanced glycoxidation end products（ AGEs）,receptor of advanced glycoxidation end products（ RAGE）,soluble receptor of advanced glycoxidation end products（ sRAGE） in nucleus pulposus and serum of patients with degenerative lumbar spondylolisthesis（ DLS）,and to explore their correlation with patient＇s prognosis.Methods Eighty patients with degenerative lumbar spondylolisthesis were randomly selected as trial group,moreover,80 healthy subjects were served as control group.The changes of AGEs,RAGE,sRAGE in nucleus pulposus and serum were detected before and after treatment to analyze the correlation among the three factors and their relationship with patient＇s prognosis.Results The levels of AGEs,RAGE in nucleus pulposus and serum in trial group were significantly increased（ P〈0.05）,however,the levels of sRAGE were significantly decreased（ P〈0.05）.The changes of AGEs,RAGE in nucleus pulposus and serum were positively correlated to the severity of DLS（ P〈0.05）,however,the levels of sRAGE were negatively correlated to the severity of DLS（ P〈0.05）.The changes of AGEs,RAGE,sRAGE in nucleus pulposus were positively correlated to those in serum（ P〈0.05）.Conclusion The levels of AGEs,RAGE,sRAGE in nucleus pulposus and serum of patients with degenerative lumbar spondylolisthesis are positively correlated to the severity of disease,however,the levels of sRAGE are negatively correlated to the severity of disease.Furthermore the levels of AGEs,RAGE,sRAGE in nucleus pulposus are positively related with those in serum.