原发性乳房外Paget病中雄激素受体的表达

Expression and significance of androgen receptor in primary extramammary Paget's disease

目的探讨雄激素受体（AR）在原发性乳房外Paget病组织中的表达及其与疾病侵袭性间的关系。方法应用免疫组化方法．检测20例原位乳房外Paget病、18例侵袭性乳房外Paget病石蜡组织切片中AR的表达情况。结果38例原发性乳房外Paget病中男26例，女12例，年龄（45～84）岁，平均年龄为64岁。AR在原发性乳房外Paget病中明显表达，AR高表达率为58％（22／38）；其中，AR在侵袭性及原位乳房外Paget病中的高表达率分别为78％（14／18）和40％（8／20），相比具有统计学意义（X2值为5．401．P值为0．020）。结论AR的异常表达与原发性乳房外Paget病的发生发展及侵袭性可能有关。

Objective To investigate the expression of androgen receptor（AR） in extramammary Paget＇ s disease,flngding the association between expres- sion level and invasive level of disease. Methods Immunohistochemistry was performed to detect the AR expression in this disease. Tissue speciments were obtained from 20 samples of extramammary Paget＇ s disease in situ and 18 samples of invasive extramammary Paget＇ s disease. Results Among all the sam- pies detected, there were 26 men and 12 women. The average age was 64 years old （45-84 ）. AR was markedly expressed in primary extramammary Paget＇ s disease. The high-expression rate of AR was totally 58% （22/38）, in which, it is significantly elevated in invasive extramammary Paget＇ s disease compared with that in extramammary Paget＇ s disease in situ [ 78 % （ 14/18 ） vs. 40% （ 8/20 ） , X2 = 5. 401, P = 0. 020 ]. Conclusion The abnormal expression of AR may be related to occurrence, develepment and invasivenese of primary extramammary Paget＇ s disease.