摘要
目的观察miR-9在胃癌组织中的表达水平及其与临床病理的相关性。方法采用实时荧光定量PCR方法分别检测28例胃癌及正常胃组织中miR-9的表达水平,并分析其表达情况与临床病理资料的关系。结果胃癌组织miR-9的表达水平[0.0078（0.0031~0.0142）]显著低于相应正常胃组织[0.0177（0.0084~0.0311）,P〈0.05],尤其是伴淋巴结转移者[0.0021（0.0006~0.0685）]miR-9表达水平明显降低。结论胃癌组织中miR-9低表达,且与胃癌淋巴结转移有关。
Objective To investigate the correlation between the level of miR-9 expression and clinicopathology in gastric carcinoma. Methods The expression of miR-9 in 28 cases of gastric carcinoma tissues and normal gastric tissues were detected by quantitative real-time PCR,and the relationship between the expression and clinicopathology was analyzed. Results The expression of miR-9 expression in gastric carcinoma tissues [0. 0078（ 0. 0031 ~ 0. 0142） ]was significantly lower compared with the corresponding normal gastric tissues [0. 0177（ 0. 0084 ~ 0. 0311）,P 〈 0. 05],especially in lymph node-invasive carcinoma [0. 0021（ 0. 0006 ~ 0. 0685） ]. Conclusion miR-9 was down regulated in gastric cancer tissues,which was significantly associated with lymph node metastasis.
出处
《广州医药》
2016年第3期8-10,共3页
Guangzhou Medical Journal
关键词
胃肿瘤
临床病理学
逆转录聚合酶链反应
MIR-9
Gastric neoplasms
Clinicopathology
Reverse transcriptase polymerase chain reaction
miR-9
