白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性研究

The correlation of cytokine level of peripheral blood cells,clinical classification and skin lesion in primary diagnosis patients with vitiligo

目的探讨白癜风初诊患者外周血细胞因子水平与临床分型、皮损面积的相关性。方法收集我院2009年7月—2013年7月4年间收治的初诊白癜风患者78例及健康志愿者37例,用ELISA检测外周血血清IL-6、IL-2,IFN-γ、TNF-α浓度并判断其与白癜风分型、皮损程度的相关性。结果与对照组相比,白癜风各分型组的IL-6、IL-2水平均升高,其中,散在性的升高幅度最为明显。IL-6及IL-2与皮损面积呈正相关,其相关系数分别为0.664及0.483,P值分别为0.021及0.014。结论 IL-2及IL-6在白癜风的发病过程中起重要作用,且在不同的分型中的表达存在差异,并与皮损面积呈正相关。

Objective To evaluate the correlation of cytokine level of peripheral blood cells,clinical classification and skin lesion in preliminary diagnosis of vitiligo. Methods A total of 78 patients with vitiligo of preliminary diagnosis and 37 health volunteers were collected from July 2009 to July 2013. The peripheral blood were collected for ELISA measurement of IL-6,IL-2,IFN-γand TNF-α,and evaluated whether the cytokines concentration was correlated to clinical classification and skin lesion. Results Compared to control group,IL-6 and IL-2 in all of classification of vitiligo was higher,and the most increase was observed in scattered group. Both IL-6 and IL-2 showed the positive correlation with skin lesion（ CI： 0. 664 and 0. 483,P =0. 021 and 0. 014）. Conclusion IL-2 and IL-6 maybe play a key role in vitiligo etiology,and showed different level in different classification of vitiligo. Besides,they showed a positive correlation with skin lesion.