儿童肾病综合征红细胞分布宽度与肾功能损害的相关分析

Correlation analysis of red cell distribution width and renal function damage in children with nephrotic syndrome

目的探讨儿童肾病综合征(NS)的红细胞分布宽度(RDW)与肾功能损害的关系。方法收集168例NS患者作为观察组,根据e GFR分期分为三组,按照起病时长4月为界限分为两组;选健康儿童100例为对照组。检测各组血常规、肝肾功能等,采用SPSS 21.0软件进行统计分析。结果 1与对照组相比,NS患儿的RBC[(4.86±0.69)vs(4.32±0.48)],RDW[(13.39±1.69)vs(12.99±1.04)]升高,差异有统计学意义(P<0.05);2RDW在肾功能3期(14.60±1.36)较2期(12.84±0.79)升高,在起病时长≤4月患儿(13.66±1.78)较健康儿童(12.99±1.04)上升,差异有统计学意义(P<0.05);红细胞平均容积(MCV)在起病时长≤4月较对照组下降,起病时间>4月组较起病时长≤4月上升,差异有统计学意义(P<0.05)。结论儿童NS患者的RBC、RDW较健康儿童升高,RDW在肾功能3期较2期升高。

Objective To investigate the relationship between red cell distribution width（ RDW） and renal function damage in children with nephrotic syndrome（ NS）. Methods 168 NS patients were chosen as the observation group,divided into three groups by e GFR level,while also divided into two groups by onset duration of 4 months. 100 healthy children were included as the control group. The blood routine,biomedical function of liver and kidney were detected. Data were analyzed by SPSS 21. 0. Results 1 Compared to control group,NS patients have higher levels of RBC [（ 4. 86 ± 0. 69） vs（ 4. 32 ±0. 48） ] and RDW [（ 13. 39 ± 1. 69） vs（ 12. 99 ± 1. 04） ],P 〈 0. 05; 2 RDW is higher in the third phase of renal function than the second [（ 14. 60 ± 1. 36） vs（ 12. 84 ± 0. 79） ],and also higher in the onset duration of less than 4 months group than the control group [（ 13. 66 ± 1. 78） vs（ 12. 99 ± 1. 04） ],P 〈 0. 05; Mean corpuscular volume is lower in the onset duration group of less than 4 months than the control group,and higher in the onset duration group more than 4 months than the onset duration group of less than 4 months,P 〈 0. 05. Conclusion The RBC,RDW are higher in children NS patients than in the healthy children; RDW is higher in the third renal function than the second renal function.