西黄胶囊减轻肺癌化疗毒副反应的临床效果观察

Clinical efficacy of Xihuang Capsule on alleviating adverse reactions of chemotherapy in lung cancer

目的观察西黄胶囊减轻肺癌全程化疗毒副反应的效果。方法 40例拟行GP方案(吉西他滨+顺铂)化疗的晚期肺癌患者,其中20例为对照组,仅用GP方案化疗,20例为观察组,在对照组的化疗方案基础上加服西黄胶囊,疗程为6个周期。化疗结束后比较两组患者近期疗效、骨髓抑制、胃肠道反应及转氨酶升高等毒副反应发生情况。结果观察组近期疗效好于对照组(P<0.05)。化疗后两组的血红蛋白毒副反应分级及转氨酶升高比例比较,差异均无统计学意义(P>0.05);观察组血小板、白细胞的毒副反应分级均低于对照组(P<0.05),胃肠道反应持续时间短于对照组(P<0.05)。结论西黄胶囊在肺癌全程化疗中可以减轻患者部分化疗药物的毒副作用。

Objective To observe the efficacy of Xihuang Capsule on alleviating the adverse reactions of chemotherapy in lung cancer. Methods Among 40 patients with advanced lung cancer planned to receive GP chemotherapy protocol（ gemcitabine and cisplatin）,twenty patients in the control group were treated with GP chemotherapy protocol,while the other 20 patients in the observation group were administered orally Xihuang Capsule on the basis of GP chemotherapy protocol. The treatment lasted for 6 cycles. After chemotherapy,the short-term efficacy of chemotherapy and the incidences of adverse reactions,including bone marrow suppression,gastrointestinal reaction and elevation of aminotransferase,were compared between two groups. Results The short-term efficacy of observation group was superior to that of control group（ P〈0. 05）. After chemotherapy,there was no significant difference in the adverse reaction grade of hemoglobin or the number of elevated aminotransferase cases between two groups（ P〉0. 05）. The adverse reaction grades of platelet and white blood cell in the observation group were lower than those in the control group（ P〈0. 05）,and the lasting duration of gastrointestinal reaction in the observation group were shorter than that in the control group（ P〈0. 05）. Conclusion Xihuang Capsule can alleviate some adverse reactions of chemotherapy drugs during whole-course chemotherapy in patients with lung cancer.