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6-溴-8-叔丁基-5H-[1,2,4]三嗪并[5,6-b]吲哚-3-硫醇类化合物的合成（英文） 被引量：1

Synthesis of novel 6-bromo-8-(tert-butyl)-5H-[1,2,4]triazino[5,6-b]indole-3-thiols
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摘要 5-叔丁基靛红(1)与N-溴代丁二酰亚胺(NBS)在环境友好的聚乙二醇-400(PEG-400)为溶剂的条件下进行溴代反应,生成5-叔丁基-7-溴靛红(2a)。随后,其在NaH为碱、DMF为溶剂的条件下发生烷基化反应,生成N-烃基取代的5-叔丁基-7-溴靛红2b-f。化合物2a-f与硫代氨基脲(3)反应得到一系列结构新颖的6-溴-8-叔丁基-5H-[1,2,4]三嗪并[5,6-b]吲哚-3-硫醇衍生物4a-f。 The synthesis of a series of structural newly 6-bromo-8-（ tert-butyl）-5H-[1,2,4]triazino[5,6-b]indole-3-thiol derivatives 4a-f had been achieved via the condensation reaction of 7-bromo-5-tert-butylisatins 2a-f with thiosemicarbazide（ 3）. The substrate 2a was prepared through the bromination reaction of 5-tert-butylisatin（ 1） with N-bromosuccinimide（ NBS） using eco-friendly PEG-400 as solvent,which was further alkylated in DMF in the presence of NaH to give the corresponding substrates 2b-f.
作者 符鑫博 白仁青卓玛 赵勋章 李阳
机构地区 渤海大学化学化工学院 锦州市第八中学
出处 《化学研究与应用》 CAS CSCD 北大核心 2016年第6期884-890,共7页 Chemical Research and Application
基金 国家自然科学基金项目(21402011)资助
关键词 三嗪并[5 6-b]吲哚 靛红 硫代氨基脲 溴代 聚乙二醇-400 triazino[5 6-b]indole isatin thiosemicarbazide bromination PEG-400
分类号 O625 [理学—有机化学]
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参考文献20

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化学研究与应用
2016年 第6期

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