丹红注射液不良反应360例文献分析

Analysis of 360 Cases of ADR Induced by Danhong Injection

目的:了解丹红注射液不良反应(ADR)发生的特点和一般规律,为临床合理用药提供参考。方法:以"丹红注射液""不良反应"为主题词,检索中国知网中国学术期刊全文数据库2005-2015年收载的期刊文献,对患者性别、年龄、原患疾病及过敏史、合并用药、ADR发生时间及临床表现进行统计、分析。结果:共检索得到有效文献24篇,共计360例患者。其中,女性多于男性(66.11%vs.33.89%);多在用药30 min内发生(169例,46.94%);ADR临床表现以皮肤及其附件损害(163例,42.89%)、全身性损害(72例,18.95%)为主,严重者可致过敏性休克。结论:临床应严格掌握丹红注射液的适应证,辨证施治、合理用药,对用药过程严密观察,警惕ADR的发生。

OBJECTIVE：To investigate the characteristics and general regularity of ADR induced by Danhong injection,and to provide reference for rational drug use in the clinic. METHODS：Using＂Danhong injection＂and＂ADR＂as keywords,retrieved from CJFD,literatures published during 2005-2015 were collected and analyzed statistically in repsects of patient＇s gender and age,disease and allergic history,drug combination,occurrence time of ADR and clinical manifestations,etc. RESULTS：A total of 24 literatures were collected,involving 360 cases. Female patients were more than male（66.11% vs. 33.89%）;ADR often occurred within 30 min during medication（169 cases,46.94%）;main clinical manifestations were lesion of skin and its appendents（163 cases,42.89%）, systemic injury（72 cases,18.95%）. The severe one would suffer form allergic shock. CONCLUSIONS：Great importance should be attached to the indication of Danhong injection,treatment based on syndrome differentiation,rational drug use and close monitoring. Constant vigilance is necessary to the occurrence of ADR.