加味酸枣仁颗粒治疗脑瘫睡眠障碍的临床研究

Clinical Research of Modified Suanzaoren Granule in Treating Sleep Disorders of Cerebral Palsy

目的探讨加味酸枣仁颗粒对脑性瘫痪患儿睡眠障碍的临床疗效。方法将62例符合标准的患儿随机分为2组,其中治疗组32例服用加味酸枣仁颗粒,每日1剂,分3次水冲服,对照组30例服用苯巴比妥片,每次2.5mg/kg,每晚睡前服一次,疗程2周。结果治疗组显效18例,有效11例,无效3例,总有效率90.63%;对照组显效11例,有效9例,无效10例,总有效率66.67%。两组总有效率比较有显著性差异(P<0.05)。结论加味酸枣仁颗粒可显著改善脑性瘫痪患儿的睡眠障碍,疗效优于对照组,且无明显的不良作用。

Objective To probe into the clinical effects of modified Suanzaoren granule in treating sleep disorders of cerebral palsy in children. Methods 62 children patients met the criterion were randomly dived into 2 groups,of which the treatment group included 32 cases took modified Suanzaoren granule,taking a daily portion by three times,and the control group of 30 cases took phenobarbitone tablet by2. 5 mg / kg per time,taking before sleep every night for 2 weeks. Results In the treatment group,18 cases had significant effects,11 cases were effective,3 cases were ineffective,and the total effective rate was 90. 63%. In the control group,11 cases had significant effect,9cases were effective,10 cases were ineffective,and the total effective rate was 66. 67%. The total effective rates of two groups had significant difference（ P〈0. 05）. Conclusion The modified Suanzaoren granule can remarkably improve sleep disorders with cerebral palsy in children,has less side-effect,and is superior to the control group.