双联抗血小板疗程对经皮冠状动脉介入治疗置入药物洗脱支架患者疗效的影响

Effect of dual antiplatelet therapy duration on patients undergoing percutaneous coronary intervention with drug-eluting stents

目的观察双联抗血小板（DAPT）疗程对经皮冠状动脉介入治疗（PCI）置入药物洗脱支架（DES）患者疗效的影响。方法 PCI置入DES的冠心病患者117例,术后口服阿司匹林（100 mg/d）和氯吡格雷（75 mg/d）,记录DAPT时间及主要不良心血管事件（MACE）情况,分析DAPT疗程对疗效的影响。结果随访时间24-30个月。出院后6个月,106例（90.6%）坚持DAPT;出院后2 a,47例（40.2%）坚持DAPT。19例（16.2%）发生MACE,其中1-2 a组、〉2 a组MACE发生率均低于〈0.5 a组（P〈0.05）。结论置入DES的冠心病患者疗效与DAPT疗程显著相关。

Objective To observe the effect of dual anti-platelet therapy（DAPT） duration on patients receiving percutaneous coronary intervention（PCI） with drug-eluting stents（DES）. Methods A total of 117 patients with coronary heart disease underwent PCI with DES were treated with oral aspirin（100 mg/d） and clopidogrel（75 mg/d）. The DAPT duration and major adverse cardiovascular events（MACE） were recorded and their relationship was analyzed. Results All patients were followed up for 24-30 months, of which 106（90.6%） and 47（40.2%） cases continued the DAPT after 0.5 and 2 years, respectively. MACE occurred in 19（16.2%） cases. The prevalence of MACE was lower in patients with DAPT duration more than 1 year compared with DAPT duration less than 0.5 year（P〈0.05）. Conclusion Clinical efficacy is correlated with DAPT duration in patients undergoing DES.