牛肺泡表面活性物质治疗新生儿呼吸窘迫综合征25例

Cattle alveolar surface active substance treatment of 25 cases of neonatal respiratory distress syndrome

目的探讨肺泡表面活性物质治疗新生儿呼吸窘迫综合征的疗效。方法新生儿呼吸窘迫综合征48例,随机分为两组,治疗组25例,对照组23例。对照组常规治疗加呼吸机辅助治疗。治疗组在对照组的基础上,加用牛肺泡表面活性物质经气管插管给药,测定两组机械通气相关指标、疗效指标、并症发生率等。所获数据采用方差分析,t检验和X^2检验。结果对照组呼吸机使用时间平均71.4 h,治疗组呼吸机使用时间平均50.1 h。两组比较,t=2.9815,P<0.005,有显著性差异。治疗组治愈或好转24例,占96.00%;对照组治愈或好转16例,占69.56%,两组比较,X^2=4.2740,P<0.05,有显著性差异。两组治疗4 h后气血分析中,PaO_2、SaO_2、PaO_2/FiO_2比较t=2.5970~6.4022,P<0.01~0.001。结论肺泡表面活性物质治疗新生儿呼吸窘迫综合征效果显著,值得推广。

Objective To investigate the cattle alveolar surface active substance curative effect for the treatment of neonatal respiratory distress syndrome. Methods 48 cases of neonatal respiratory distress syndrome were randomly divided into two groups： treatment group（25 cases, 23 cases of control group. The control group routine treatment plus breathing machine auxiliary treatment. Treatment group in the control group, on the basis of the total cattle alveolar surface active substance by endotracheal intubation, the determination of two groups of related parameters of mechanical ventilation, curative effect and the incidence of complications after treatment. The data obtained using analysis of variance, t test and X-2 test.Results the control group respirator use time average 71.4 h, treatment group respirator use time average 50.1 h. Comparing the two groups, t = 2.9815, P〈0.005, there is significant difference. The treatment group 24 cases were cured or improved, accounted for 96.00%; The control group 16 cases were cured or improved, accounted for 69.56%, compared two groups, X-2= 4.2740, P〈0.05, there is significant difference. In the two groups after treatment of 4 h blood analysis, PaO_2,SaO_2, PaO_2/ FiO_2 is t = 2.5970 - 6.4022, P〈0.01 - 0.001. Conclusion cattle alveolar surface active substance has the significant effect of neonatal respiratory distress syndrome, is worth promoting.