检测前降钙素原和C反应蛋白水平对疟疾患者的诊治意义

Diagnosic and treatment significance of plasma procalcitonin and C-reactive protein in patients with malaria

目的检测血浆前降钙素原(PCT)以及C反应蛋白(CRP)水平,分析对疟疾患者诊治的临床意义。方法选择疟疾患者33例,分为重症疟疾患者组和非重症疟疾组,比较分析两组患者PCT、CRP、血红蛋白(Hb)、血清谷丙转氨酶(ALT)、总胆红素(TB)、凝血酶原时间(PT)、血钾等指标。结果重症疟疾组的PCT水平明显高于非重症疟疾组,差异有统计学意义(t=-3.75,P<0.05)。两组疟疾患者的CRP水平较正常值均有明显升高,重症疟疾组的CRP水平仍明显高于非重症疟疾组,差异有统计学意义(t=-4.68,P<0.05)。重症疟疾组的Hb水平明显低于非重症疟疾组,差异有统计学意义(t=2.36,P<0.05)。但两组间TB、ALT、PT、血钾比较,差异均无统计学意义(t分别=-1.55、-0.16、-0.94、-0.52,P均>0.05)。结论 PCT和CRP可作为评估疟疾患者病情严重程度的重要指标。

Objective To evaluate the clinical significance of plasma procalcitonin（PCT） and C-reactive protein（CRP）in patients with malaria. Methods A total of 33 cases of malaria were selected and divided into the severe malaria group and non-severe malaria group. The PCT, CRP, Hb, ALT, TB, PT and serum potassium between two groups were detected and compared. Results The PCT of the severe malaria group was significantly higher than non-severe malaria group as well as the CRP（t=-3.75,-4.68, P〈0.05）. The concentration of Hb of severe malaria group was significantly lower than non-severe malaria group（t =2.36,P 0.05）. There was no statistical difference of TB, ALT, PT and serum potassium between two groups（t=-1.55,-0.16,-0.94,-0.52, P〉0.05）. Conclusion PCT and CRP can be as indexes to assess the severity of malaria.