摘要
目的制备印奇果油-羟丙基-β-环糊精包合物。方法采用饱和溶液法制备印奇果油-羟丙基-β-环糊精包合物;采用L9(34)正交设计,优化印奇果油-羟丙基-β-环糊精包合物制备工艺;采用喷雾干燥法将其制备成粉末;采用单因素分析法优化印奇果油-羟丙基-β-环糊精包合物的最佳喷雾干燥工艺。结果以包合率为指标,印奇果油-羟丙基-β-环糊精包合物的最佳制备工艺为A2B1C2,即当包合温度为60℃,搅拌时间为30 min,药液滴加速度为1 m L/min时,包合率最高。按最佳工艺参数进行3次平行试验,平均包合率为36.94%,相对标准偏差(RSD)为1.06%。结论以最佳工艺制备包合物,工艺稳定可行。
Objective To prepare hydroxypropyl-β-cyclodextrin inclusion complex of Sacha inchi oil. Methods The hydroxypropyl-β-cyclodextrin inclusion complex of Sacha inchi oil was prepared by saturated solution method. The preparation technology was optimized by L9 （3^4） orthogonal test. The powder of inclusion complex was prepared by spray drying, and the spray drying process was optimized by single factor analysis approach. Results The optimum preparation technology of the inclusion complex is A2B1C2 （the inclusion temperature of 60℃, the stirring time of 30 min, and the drug solution drop rate of 1 mL/min）. According to the optimum technology, the mean inclusion rate of three parallel tests was 36.94 %, and the relative standard deviation （RSD） was 1.06 %. Conclusion The optimum technology is stable and feasible.
出处
《食品与药品》
CAS
2016年第3期153-155,共3页
Food and Drug
基金
国家自然科学基金项目(No.81173645)
