放松训练对肺癌患者顺铂致急性及延迟性恶心呕吐的影响

Effect of relaxation training on acute and delayed nausea and vomiting induced by cisplatin in lung cancer patients

目的探讨渐进性肌肉放松训练对肺癌患者顺铂所致急性和延迟性恶心呕吐的干预效果。方法将72例肺癌顺铂化疗患者按时间段分为对照组和干预组各36例,两组均按常规治疗护理,干预组增加渐进性肌肉放松训练,连续7d后评价效果。结果急性期两组呕吐频次、恶心程度差异无统计学意义(均P>0.05),呕吐例次干预组显著少于对照组(P<0.01);延迟期干预组呕吐频次、恶心程度、呕吐例次显著少于对照组(均P<0.01)。结论渐进性肌肉放松训练可有效降低顺铂所致的延迟期呕吐频次及恶心程度,对急性期恶心呕吐的缓解作用较弱。

Objective To explore the effect of progressive muscle relaxation training（PMRT）on acute and delayed nausea and vomiting induced by cisplatin in lung cancer patients.Methods Totally,72 lung cancer patients who underwent cisplatin chemotherapy were equally randomized into a control group and an intervention group according to chronological order,receiving either routine nursing care or PMRT respectively.The effect was evaluated 7days after the intervention.Results During the acute phase,there were no significant differences in frequency of vomiting and severity of nausea between the two groups（P0.05 for both）,whereas less patients in the intervention group vomited（P0.01）.During the delayed phase,the frequency of vomiting,severity of nausea,and the number of patients who vomited in the intervention group were significantly less/milder than the control group（P0.01 for all）.Conclusion PMRT can effectively reduce frequency of vomiting and severity of nausea induced by cisplatin in delayed phase,while the effect in acute phase is not remarkable.