盐酸氟西汀联合醒脑静注射液治疗对脑出血吸收率及焦虑障碍的临床研究

Clinical Curative Effect of Fluoxetine Hydrochloride Combined with Xingnaojing Injection on Patients with Cerebral Hemorrhage

目的:探讨盐酸氟西汀联合醒脑静注射液对脑出血吸收率及焦虑障碍的治疗效果。方法:选取2011年3月-2015年3月本院接收的脑出血患者100例,随机数字表法分为试验组50例和对照组50例,所有患者均给予常规处理:减轻脑水肿、调整血压、维持酸碱平衡、抗感染等。在此基础上,试验组采用盐酸氟西汀联合醒脑静注射液治疗,用法为:给予醒脑静30 mL加入100 mL 0.9%氯化钠溶液静脉输注,1次/d,另服用盐酸氟西汀胶囊,20 mg/次,1次/d;对照组则单纯采用醒脑静注射液治疗,用法为:单纯给予醒脑静30 mL加入100 mL 0.9%氯化钠溶液静脉输注,1次/d;两组患者均以14 d为一疗程。比较两组患者治疗前后脑血肿的吸收情况,观察两组患者治疗前后抑郁、焦虑情绪及神经功能缺失程度评分(NDS)的变化。结果:经过一疗程的治疗后,两组患者脑血肿的面积均缩小,且试验组的缩小程度大于对照组,差异有统计学意义(P<0.05)。试验组脑水肿吸收的总有效率为98.00%,明显高于对照组的60.00%,差异有统计学意义(P<0.05)。两组患者的NDS评分、抑郁评分(SDS)及焦虑评分(SAS)较治疗前均明显降低,且试验组的下降幅度均大于对照组,差异均有统计学意义(P<0.05)。结论:盐酸氟西汀联合醒脑静注射液治疗脑出血疗效显著,可以有效缩小血肿面积,恢复神经功能,同时改善患者的抑郁、焦虑情绪。

Objective：To evaluate the clinical curative effect of Fluoxetine Hydrochloride combined with Xingnaojing Injection on patients with cerebral hemorrhage.Method：A total of 100 patients with cerebral hemorrhage from March 2011 to March 2015 in our hospital were selected and randomly divided into two groups.All patients were given routine treatment：reduced brain edema,adjusted blood pressure,maintained acidbase balance, anti infection etc.On this basis,the experimental group（ n=50） received Fluoxetine Hydrochloride combined with Xingnaojing Injection,and the control group（ n=50） received Xingnaojing Injection,compared the absorption of hematoma in two groups before and after treatment.The changes of SAS,SDS and NDS score of the two groups were observed before and after treatment.Result：After treatment,the area of cerebral hematoma in two groups were reduced,and the reduction degree in the experimental group was bigger than that in the control group,the difference was statistically significant（ P〈0.05）.Total effective rate of cerebral edema absorption in the experimental group（ 98.00%） was significantly higher than the control group（ 60.00%）,the difference was statistically significant（ P〈0.05）.The NDS score,SAS score and SDS score were significantly lower than before treatment,and the decline range in the experimental group were bigger than that in the control group,the difference were statistically significant（P〈0.05）.Conclusion：Fluoxetine Hydrochloride combined with Xingnaojing Injection to treat cerebral hemorrhage has a good curative effect,can effectively reduce the hematoma area,recover nerve function and improve the patients＇ mood of depression and anxiety.