注射用硝普钠与氯化钠注射液配伍后使用时间延长至26小时的临床研究

Clinical Study on Compatibility of Sodium Nitroprusside for Injection and Sodium Chloride Injection after Prolonged Use to 26 h

目的为注射用硝普钠与氯化钠注射液临床合理配伍提供参考。方法选择3组高血压危象患者,分别静脉滴注配制4 h内（A组,n=28）、12~14 h内（B组,n=29）、24~26 h内（C组,n=33）注射用硝普钠与氯化钠注射液配伍液,检测各组患者血液中氰酸盐含量,并同时进行血气分析,记录硝普钠的用量;对配伍后26 h硝普钠配伍液的降解度和氰化物含量进行检测。结果按常规配制,使用注射用硝普钠与氯化钠注射液配伍液26 h内是安全有效的。结论临床上延长注射用硝普钠与氯化钠注射液配伍液使用时间至26 h是可行的。

Objective To provide scientifi c basis for clinical rational compatibility of sodium nitroprusside（SNP） for injection and sodium chloride（NS） injection. Methods The compatible solution of SNP and NS injection was given intravenously in three ways for the patients in 3 different groups of hypertensive crisis. The solution was given within 4 h, 12 to 14 h, and 24 to 26 h after preparation for each group of patie nts respectively. The blood contents of cyanide（CN） were measured, and blood gas analyses were performed at the same time, and the amounts of the SNP used were recorded. The contents of CN and the degradation of sodium nitroprusside in the compatible solution of SNP and NS injection were also measured 26 h after its preparation. Results As convent ional preparation, the compatible solution of SNP and NS injection used within 26 h is safe and effective. Conclusion It is scientifi c to use the compatible solution of SNP and NS injection until 26 h after its preparation in clinic.