醒脑静注射液对高血压基底节区脑出血患者脑水肿与血清AQP4的影响

The effects of Xingnaojing injection on brain edema induced by hypertensive basal ganglia hemorrhage and the level of serum AQP4

目的探讨醒脑静注射液治疗高血压基底节区脑出血的临床疗效及治疗前后的脑水肿与血清AQP4水平。方法选取2011-2013年我院收治的高血压基底节区脑出血患者40例,随机平均分为2组,分别行常规治疗与联合醒脑静注射液治疗。结果治疗2周后观察组显效率与总有效率均明显高于对照组(P<0.05),治疗后观察组NIHSS评分、脑水肿体积以及血清AQP4水平改善明显优于对照组(P<0.05)。结论醒脑静注射液能够有效改善高血压基底节区脑出血的治疗效果,有效促进脑水肿的吸收与恢复,降低血清AQP4水平,具有较高的临床价值。

Objective To study the effects of Xingnaojing injection on brain edema induced by hypertensive basal ganglia hemorrhage and the level of serum AQP4.Methods Forty patients with hypertensive basal ganglia hemorrhage in our hospital from 2011 to 2013were randomly divided into two groups,which respectively received routine treatment and combined therapy of Xingnaojing injection and routine treatment.Results After treatment for 2weeks,the efficiency rate and total effective rate of observation group were significantly higher than those of control group（P〈0.05）.Additionally,NIHSS scores,cerebral edema volume and level of serum AQP4 in the observation group were significantly improved compared with those in the control group（P〈 0.05）.Conclusion Xingnaojing injection can obviously improve the curative effect,can effectively promote the absorption and recovery of cerebral edema and can reduce the level of serum AQP4,which has high clinical value in patients with hypertensive basal ganglia hemorrhage.