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精神分裂症患者认知功能与临床特征关系分析 被引量：6

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摘要 目的探讨精神分裂症患者认知功能与临床特征的关系。方法采用事件相关电位(Event-related Potentials,ERP)P300和探究性眼动分析(exploratory eye movement,EEM)评估患者组及对照组的认知功能,同时采用阳性和阴性症状量表(PANSS)评定患者的精神症状。结果患者组P300潜伏期较对照组延长,波幅降低,EEM中NEF及RSS减少,D值增加,差异均具有统计学意义(P<0.01)。患者组P300潜伏期与PANSS量表一般状况分、思维障碍评分及激活性评分均呈负相关(P<0.05),波幅与PANSS量表阴性症状分及一般状况分均呈负相关(P<0.01,P<0.05);EEM中凝视点数(NEF)与阴性症状分呈负相关(P<0.05),PANSS总分与反应性探索评分(RSS)呈负相关(P<0.05),与D值呈正相关(P<0.01)。结论 P300和EEM测定可作为精神分裂症认知功能诊断的参考指标之一;阴性症状的严重程度是影响精神分裂症患者认知功能的主要因素。
作者 李猛 朱俊敬 张淑芳 李文峰 付慧鹏
机构地区 郑州市第八人民医院
出处 《中国实用神经疾病杂志》 2016年第10期59-60,共2页 Chinese Journal of Practical Nervous Diseases
关键词 精神分裂症 认知功能 临床特征 事件相关电位 探究性眼动分析
分类号 R749.3 [医药卫生—神经病学与精神病学]
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参考文献10

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共引文献8

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二级引证文献18

中国实用神经疾病杂志
2016年 第10期

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