响应面法优化辣椒碱β-环糊精包合物制备工艺

Optimization of Preparation Conditions for Capsaicin-β-cyclodextrin Inclusion Complex by Response Surface Methodology

利用饱和水溶液法制备辣椒碱β-环糊精包合物,以包合率和包合物产率为评价指标,通过对包合温度、包合时间及配料比的考察,以响应面法优选最佳工艺条件。结果表明,辣椒碱β-环糊精包合物的最佳包合条件为包合温度50℃,包合时间为3 h,配料比为1∶1(摩尔比),此时包合物平均产率为53.97%,平均包合率为52.51%。采用响应面法可优化辣椒碱β-环糊精包合物的制备工艺,为辣椒碱药物制剂的研发提供借鉴。

The inclusion complex was prepared by saturated solution method with inclusion ratio and yield of capsaicin- β-cyclodextrin inclusion complex as indexes, influence of inclusion temperature, inclusion time,and ratio of capsaicin-β-cyclodextrin to inclusion process were investigated by response surface method. Optimum inclusion technology of capsaicin- β-cyclodextrin inclusion complex were as follows：nclusion temperature of 50 ℃,inclusion time of 3 h,ratio of capsaicin-β-cyclodextrin of1∶1. Under the optimized conditions, the yield of capsaicin-β-cyclodextrin inclusion complex was 53.97%,and the inclusion ratio was 52.51%. Using response surface methodology to optimize preparation of capsaicin- β-cyclodextrin inclusion complex had good prediction, and the optimized preparation could be helpful for developing capsaicin agent.