摘要
目的：探讨不同类型癫痫大鼠在急性期和慢性期反复自发性发作时、发作前后脑电图（EEG）相应指标改变以及行为学改变。方法：选取雄性SD大鼠40只，随机分为A、B、C、D4组。A组10只为杏仁核电点燃癫痢模型（不作电刺激）对照组；B组：10只，为制作杏仁核电刺激点燃癫痫模型组；C组：10只，氯化锂-匹罗卡品癫痫模型（只注生理盐水）对照组；D组：10只，制作氯化锂一匹罗卡品癫痫模型组。结果：D组慢性期发作时EEG频率与急性期频率相比差异有统计学意义（P〈0．05），与B组各时期相比差异有统计学意义（P〈0．05）；D组慢性期发作后3min发作频率与B组急性期相比差异有统计学意义（P〈0．05）；A组与C组在频率、波幅方面比较差异无统计学意义（P〉0．05）。结论：B、D两种不同类型的癫痫大鼠不同时期EEG和行为学都会发生相应的改变。
Objective：To explore the effect of different types and change of the epileptic seizure in rats on EEG and ethology. Methods：40 spraque-dawley（SD）rats were divided into 4 groups：Group A,B, C, D. In Group A, 10 rats were the normal control group;In Group B, 10 rats were made into amygdala electrical kindling models of epilepsy;In Group C, 10 rats were the normal control group; In Group D, 10 rats were made into the licl-pilocarpine models of epilepsy. Results： When the rats had epileptic seizure occured in the rats, there was significant correlation between EEG frequencies of Group D during acute phase during chronic phase（P〈0.05）, and there was significant correlation acute phase compared with EEG freguencies of Group B during all each phase（P〈0.05） ; 3 minutes after epileptic seizure. There was significant correlation between EEG frequencies of Group D during chronic phase and of Group 15 during acute phase（P〈0.05） and the difference between Group A and Group C in EEG frequencies and amplitude was not significant （P〉0.05）. Conelusion..Two different types of epileptic seizures in rats can lead to the change of EEG freguencies and ethology.
出处
《癫痫与神经电生理学杂志》
2016年第3期129-132,共4页
Journal of Epileptology and Electroneurophysiology(China)
基金
国家自然科学基金资助项目（NO：81241129/H0913）
