摘要
目的研究重组人白细胞介素-11(rh IL-11)对小鼠阴道上皮细胞有丝分裂和增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)表达的影响。方法采用雌激素周期性小鼠阴道上皮增殖银屑病实验模型及PCNA免疫组化方法,测定白细胞介素-11对小鼠阴道上皮细胞有丝分裂和PCNA表达的影响。结果白细胞介素-11可显著抑制小鼠阴道上皮细胞有丝分裂(P<0.01),并显著抑制PCNA的表达(P<0.01)。结论白细胞介素-11可明显抑制上皮细胞有丝分裂和PCNA的表达,对银屑病等表皮过度增殖性异常病变有较好的防治作用。
Objective To investigate the therapeutic effects of recombinant human interleukin-11（ rh IL-11） on the vaginal epithelium mitosis of estrone periodical mice and the exprssion of PCNA. Methods The vaginal epithelium mitosis of estrone periodical mice was used as the epidermis hyperplasia model, rh IL-11 action in regulating the epidermis hyperplasia was observed and the expression of PCNA was detected by immunohistochemistry. Results The rh IL-11 significantly inhibited the mitosis of mouse vaginal epithelium,decreased the expression of PCNA（ P〈0. 01）. Conclusion The rh IL-11 has good efficacy in treating the epidermis hyperplasia of psoriasis by inhibiting the mitosis of epithelium and decreasing the expression of PCNA.
出处
《中国生化药物杂志》
CAS
2016年第4期49-51,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
山东省科技发展计划项目(2007GG3WZ02059)
