萘哌地尔对老年前列腺炎患者血清及前列腺液MIP-2、MIP-1α水平的影响

Effect of naftopidil on levels of MIP-2 and MIP-1α in serum and succus prostaticus in the treatment of prostatitis in elderly

目的探讨萘哌地尔对老年前列腺炎患者血清以及前列腺液巨噬细胞炎性蛋白2(macrophage inflammatory protein-2,MIP-2)、巨噬细胞炎性蛋白1α(macrophage inflammatory protein-1 alpha,MIP-1α)水平的影响。方法选取老年慢性前列腺炎患者78例,随机分成对照组与观察组,每组各39例。对照组采用地奥司明常规治疗,观察组在此基础上联合萘哌地尔治疗,连续治疗8周。比较治疗前后血清及前列腺液中MIP-2、MIP-1α水平以及最大尿流速及临床疗效。结果与治疗前比,2组治疗后血清和前列腺液中MIP-2、MIP-1α水平、NIH-CPSI及QOL评分降低,最大尿流速升高(P<0.05);与对照组相比,观察组血清和前列腺液中MIP-2、MIP-1α水平、NIH-CPSI及QOL评分较低,最大尿流速较高(P<0.05);与对照组相比,观察组总有效率较高(P<0.05)。结论萘哌地尔能显著降低老年慢性非细菌性前列腺炎患者血清和前列腺液MIP-2、MIP-1α水平,改善尿痛、排尿困难等症状,不良发应少。

Objective To investigate the effect of naftopidil in the treatment of prostatitis in the elderly on MIP-2 and MIP-1α in serum and succus prostaticus. Methods 78 elderly patients with chronic prostatitis were randomly divided into the control group and the observation group,39 cases in each group. The control group were treated with Diosmin routine treatment,the observation group were treated on the basis of the control group combined with naftopidil tablets in the treatment,2 groups were treated continuous for 8 weeks. MIP-2 and MIP-1α in serum and prostatic fluid before and after treatment were compared,and the maximum urine flow rate and clinical efficacy were compared after the treatment. Results compared with pretreatment,MIP-2,MIP-1α in serum and prostate fluid in 2 groups after treatment decreased,NIH-CPSI and QOL scores in 2 groups decreased,the maximum urinary flow rate increased（ P〈0. 05）; compared with the control group,the levels of MIP-2,MIP-1αin the serum and prostatic fluid,NIHCPSI and QOL of observation group were lower,and the maximum urine flow rate was higher（ P〈0. 05）; Compared with the control group,the total efficiency of the observation group was higher（ P〈0. 05）. Conclusion Naftopidil can significantly reduce the elderly patients with chronic non bacterial prostatitis and serum of patients with prostatic fluid MIP-2,MIP-1α level and improve pain in urination,dysuria symptoms.